Originally from Singapore, 16-year old Janelle Tam of Waterloo, Ontario has won first place nationally in the 2012 Sanofi BioGENEius Challenge Canada (SBCC) competition with her application for nanocrystalline cellulose. From the May 8, 2012 news item on physorg.com,

Janelle Tam, a Grade 12 student at Waterloo Collegiate Institute, was awarded the $5,000 first prize by an impressed panel of eminent Canadian scientists assembled at the Ottawa headquarters of the National Research Council of Canada.

…

The theme of the competition, “How will you change the world?” inspired hundreds of students to participate in 2012 SBCC events Canada-wide.

…

Canada’s next big technological and health breakthrough might come from cellulose, the woody material found in trees that enables them to stand. Cellulose is made up of tiny nano-particles called nano-crystalline cellulose (NCC) that are measured in thousandths of the width of a human hair.

Only recently discovered, Waterloo’s Janelle Tam is the first to show that NCC is a powerful antioxidant, and may be superior to Vitamin C or E because it is more stable and its effectiveness won’t diminish as quickly.

“NCC is non-toxic, stable, soluble in water and renewable, since it comes from trees,” says Janelle, a Grade 12 student at Waterloo Collegiate Institute.

…

“NCC is really a hot field of research in Canada,” says Janelle, who notes that antioxidants have anti-aging and health promotion properties, including wound healing since they neutralize “free radicals” that damage or kill cells.

Janelle chemically ‘paired’ NCC with a well-known nano-particle called a buckminster fullerene. These ‘buckyballs’ (carbon molecules that look like a soccer ball) are already used in cosmetic and anti-aging products she says. The new NCC-buckyball combination acted like a ‘nano-vacuum,’ sucking up free radicals and neutralizing them.

“The results were really exciting,” she says and especially since cellulose is already used as filler and stabilizer in many vitamin products. One day those products may be super-charged free radical neutralizers thanks to NCC, she hopes.

Jeff Hicks’ May 8, 2012 story for TheRecord.com about Tam and her NCC work offers some insight into the young scientist and the scientific process,

Janelle, 16, is admittedly stubborn.

Gets it from her dad Michael, a University of Waterloo chemical engineering professor.

…

… you’ve got to have gumption to spend three to four hours a day in a University of Waterloo lab from September to March to invent a disease-fighting, anti-aging compound.

…

A frustrating nano-globe almost kicked her into submission last December.

Three months into her work she realized she had messed up. Her experimental technique was flawed. Her results were as worthless as Leafs playoff tickets.

Janelle wanted to give up. She told her mom Dorothy, a literacy social worker, she was never returning to the lab. Her older sister and former Team Canada science partner Vivienne, could not be leaned on for advice. Vivienne, 19, had left for Princeton.

…

But Janelle’s dad settled her down.

“He’s one of the most perseverant people I know,” she said. “He tells me that research is about failing and failing and failing. And failures are all steps on the way to success.”

Tam will be in Boston, Massachusetts for June 18, 2012 to compete in Sanofi’s International BioGENEius Challenge, which takes place at the same time as Sanofi’s  BIO Annual International Convention. For anyone who’s curious about Sanofi, it’s a French multinational pharmaceutical company headquartered in Paris, France. I found the Wikipedia essay a little more informative than the Sanofi company website .

(For a mild change of pace) So, Sanofi is a large French company which sponsors this contest . Are Canadian companies sponsoring contests of this type? I ask the question because Canadian companies don’t invest in research and development at the same rate as companies in other countries and, it appears, do less to stimulate  interest and participation in science pursuits amongst youth. Developing an innovative society means having a much more comprehensive approach than publicity campaigns and retooling government funding programmes.

Getting back to Tam’s work, congratulations! This is very exciting stuff especially in light of some of the concerns expressed in Bertrand Marotte’s recent article on NCC for the Globe and Mail newspaper, mentioned in my May 8, 2012 posting.

There’s more than one NCC, which I’ve used exclusively as an abbreviation for nanocystalline cellulose. There’s also nanocrystalline Cobalt according to the May 9, 2012 news item on Nanowerk highlighting another NCC and Toronto’s Integran Technologies, Inc.,

Toronto-based Integran Technologies, Inc. (Integran) today announced that it has reached an agreement with Enduro Industries LLC (Enduro) to extend Enduro’s license exclusivity term for Integran’s nanocrystalline Cobalt electroplating process, Nanovate™ CoP, in the US fluid power market by five years.

Enduro Industries LLC of Hannibal, Missouri, a subsidiary of PTC Alliance, and a major manufacturer of hard chrome steel bars and tubes for the fluid power industry, has successfully marketed a corrosion and wear resistant Nano-CobaltTM alternative alongside its conventional engineered hard chrome (EHC) ChromerodTM and Chromrod ExtremeTM product lines.

I notice they don’t use the NCC abbreviation; I imagine they would prefer to avoid any confusion.  Integran’s company president and CEO (Chief Executive Officer), Gino Palumbo goes on to hint at further developments due to this renewed licensing agreement but offers no details, from the news item,

“Furthermore, this agreement will now extend to other Cobalt-based Nanovate coatings systems and a new field repair process recently developed by Integran.”

I have mentioned Integran before, most recently in an April 16, 2012 posting about a Canadian federal government investment in the company and in a March 26, 2012 posting about a deal with Pratt & Whitney Canada.

One of the scientists on a research team at Trent University (Ontario, Canada) is claiming that safety questions about nanomaterials are not being asked and so the team is embarking on a study of silver nanoparticles and their impact on a lake ecosystem. From the May 2, 2012 news item on Nanowerk,

Dr. Chris Metcalfe, professor and director of the Institute for Watershed Science at Trent University, is the principal investigator on the Lake Ecosystem Nanosilver (LENS) project with Trent researchers, Drs. Maggie Xenopoulos, Holger Hintelmann and Paul Frost, and colleagues from Fisheries and Oceans Canada and Environment Canada.

“This is a high profile project that will have the eyes of the scientific community on Trent,” said Professor Metcalfe. “We’re fortunate that we have four world-class researchers on our team.” Over the past decade, tiny substances called nanomaterials have become part of our daily lives.

It’s possible that the clothes you’re wearing, or the sunscreen you just applied, contain nanomaterials. Because of this growing use, there is now concern that nanomaterials may pose threats to the environment.

“We have seen an exponential growth in the use of nanomaterials,” said Professor Xenopoulos, an associate professor in the Biology department at Trent University. “However, questions of safety are not being asked.” [emphasis mine]

Likely the claim is a little overenthusiasm or a lack of clarity on the speaker’s part since there has been more than one study about nanosilver particles and safety, including one at Purdue University mentioned in a March 4, 2010 posting on the Beyond Pesticides blog. The Purdue study (The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos) is behind a paywall.

Here’s a bit more about silver nanoparticles and the LENS study,

While the benefits of nanomaterials are recognized, we know little about their risks to health and the environment. Due to their extremely small size, nanomaterials interact with cells and organic molecules, raising questions about their impact on organisms.

Due to their antibacterial properties, nanosilver particles are among the most widely-used nanomaterials in consumer goods. Clothing, home appliances, paint, bandages and food storage containers are a few of the products which may contain nanosilver. As we use and dispose of these products, there is a risk that nanosilvers will travel through our municipal water systems into our lakes and rivers.

The research team is working to understand the effect of nanosilver particles on the aquatic environment. Initial laboratory research conducted at Trent indicates that nanosilver can strongly affect aquatic organisms at the bottom of the food chain, such as bacteria, algae and zooplankton.

To further examine these effects in a real ecosystem, the team is conducting a study at the Experimental Lakes Area, near Kenora, in northwestern Ontario.

The LENS project will monitor changes in a lake’s ecosystem that occur after the addition of nanosilver. It will follow nanosilver as it travels through the lake ecosystem, track effects through the entire food web, and determine how resulting changes alter ecosystem function.

There’s more about the LENS project on the Trent University LENS (Lake Ecosystem Nanosilver) Project page (excerpt),

Our previous laboratory research has shown that nanosilver in the aquatic environment first affect organisms at the bottom of the food chain, including bacteria, algae and zooplankton. These responses may have devastating effects upon aquatic ecosystems by reducing overall productivity and altering the cycling of nutrients, such as carbon, nitrogen and phosphorus. There may be compensatory mechanisms within aquatic ecosystems that can mitigate these responses, but it is impossible to predict these responses using laboratory studies. Through support from the Strategic Grants Program of the Natural Sciences and Engineering Research Council of Canada and Environment Canada, a team of researchers from Trent University, Environment Canada and Fisheries and Oceans Canada will conduct a study at the Experimental Lakes Area (ELA) in northwestern Ontario by adding nanoform silver to a small lake over two summer field seasons ion 2013-14. During nano-silver additions, we will monitor the lake for changes to nutrient cycling and the biological effects within the entire food chain. However, in 2012, before starting the lake additions, we will refine our approach by determining what happens in mesocosms (i.e. plastic tubes) that are deployed in lakes. ELA has been used for over 40 years as a living laboratory to study the effects of pollutants in the environment, including past studies of the impacts of pollution from phosphorus, acid deposition, mercury and endocrine disruptors. These studies have resulted in policies to reduce the impacts of pollution. While we do not take lightly the impact that this study will have upon a lake in ELA, this approach is the only way to determine ecosystem level impacts and to influence regulatory policy regarding the ecological risks of NMs.

This is a three-year project, which starts this year (2012).